Protein–Protein Interactions: Putting the pieces together

Protein–Protein Interactions: Putting the pieces together

What do the recently determined crystal structures of 14-3-3 proteins and of a complex between part of the protein kinase Raf and the Ras-related protein Rap tell us about how 14-3-3 and Ras regulate the function of Raf?

Putting the pieces together.

Inflammasome: Putting the Pieces Together

Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inf...

Menthol: putting the pieces together

OBJECTIVE To integrate information on cigarette companies' understanding and use of menthol as summarised in published research based on previously internal tobacco industry documents with results from large population-based surveys of tobacco use and other independent sources. DATA SOURCES Papers published in this supplement of Tobacco Control, together with papers identified using PubMed se...

ADHD : Putting the Pieces Together

Hyperactivity, impulsivity, disruptive behavior, lack of focus—the symptoms of attention-deficit/hyperactivity disorder can negatively impact children and their families. Primary care providers have the opportunity to bring a semblance of order to chaos, and improve quality of life for all involved, by identifying affected patients and providing effective treatment options. Here is everything y...